Hypertensive Vascular Disease Induced by Heterologous Renin
نویسنده
چکیده
• Crude rat renin administered to uninephrectomized rats caused hypertensive vascular disease, while semipurified hog renin in equipressor doses, as determined by bio-assay, was ineffective. To explain this difference, the following three possibilities were considered. (1) The lack of activity of hog renin in rats is due to its heterologous nature. (2) Crude rat renin contains an active principle absent in the semipurified hog renin. Or (3), the impurities in crude preparations retard renin resorption from the subcutaneous injection sites and thereby prolong its effects. In the present paper we demonstrate that the third possibility provides the most likely explanation.
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